Human Recombinant E-Selectin from CHO cells VWR

Arnika Wagner - Assistant Professor - Karolinska Institutet

1997-02-01 This together with minor differences in fucose binding, accounts for the 10-fold higher affinity of E-selectin for SLe x as compared to P-selectin. However, although P-selectin binds SLe x only with millimolar affinity (K D = 7.8 mM), very high affinities are obtained for specific glycoprotein counterreceptors (800 nM for SLe x-modified PSGL-1). E- and P-selectin as well as L-selectin are members of selec-tin family and members of a large group of adhesion molecules. They all exist in soluble forms in blood plasma, though each is synthesized or stored in different cells: E-selectin in endothelial cells, P-selectin in alpha granules of blood platelets and Weibel- E-selectin, as compared to L-selectin and P-selectin, is the redundancy of ligands through which it tethers PMN and executes a slow rolling immunosurveillance at velocities on the order of one micron per second. Another remarkable feature is that PMN rolling on E-selectin and subsequent ESL clustering transduce E-Selectin and P-Selectin are related (44% amino acid sequence identity) adhesion molecules containing multiple short complement-like repeats and an N-terminal C‑type lectin domain in their extracellular regions. E-Selectin is expressed on activated vascular endothelial cells and P-Selectin occurs on activated platelets and endothelial cells. 2018-08-02 Both E-and P-selectins are expressed on human arterial luminal endothelial cells of atherosclerotic plaques (195, 196), and mouse studies have shown that E-selectin and/or P-selectin deficiency substantially reduces the formation of atherosclerotic plaques, suggesting an overlapping function of these two selectins in the development of atherosclerotic lesions (197, 198).

P selectin vs e selectin

It is found in granules in endothelial cells and activated platelets. In unactivated endothelial cells, it is stored in granules Weibel … P-selectin–deficient (Selp −/−) mice bred with apolipoprotein E–deficient (Apoe −/−) mice or with low-density lipoprotein (LDL) receptor–deficient (Ldlr −/−) mice develop smaller atherosclerotic lesions than control mice. 15 – 18 Bone marrow transplantation experiments suggest that P-selectin on nonhematopoietic presumably endothelial cells contributes more to atherosclerosis than P-selectin on … P Selectin Human More Info P-selectin Human Recombinant PRO-382. 2µg ($50) 10µg ($130) 1mg ($4800) Shipped with Ice Packs Add to Cart. Back to Top SELE Human, HEK More Info E-Selectin Human Recombinant, HEK PRO-1645.

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They function How it works. The role of E and P- selectin begins with the inflammatory immune response. E-selectin versus P-selectin is a transmembrane protein present in the α granules of platelets and the Weibel-Palade bodies of endothelial cells. Following activation, Detects human E‑Selectin/P‑Selectin (CD62E/P).

They all exist in soluble forms in blood plasma, though each is synthesized or stored in different cells: E-selectin in endothelial cells, P-selectin in alpha granules of blood platelets and Weibel- Estrutura. Os tres membros coñecidos da familia da selectina (L-, E- e P-selectina) comparten unha estrutura en casete similar: un dominio de lectina dependente de calcio N-terminal, un factor de crecemento epidérmico dominio de tipo EGF, un número variable de unidades repetidas consenso (2, 6 e 9 para as L-, E- e P-selectina, respectivamente), un dominio transmembrana (TM) e unha cola 2021-04-15 · P-selectin plays an essential role in the initial recruitment of leukocytes (white blood cells) to the site of injury during inflammation. When endothelial cells are activated by molecules such as histamine or thrombin during inflammation, P-selectin moves from an internal cell location to the endothelial cell surface. Se han identificado a tres miembros de esta familia, los cuales corresponden a los antígenos de diferenciación leucocitaria CD62L (L-selectina), CD62P (P-selectina) y CD62E (E-selectina); estas tres moléculas reconocen y se unen, a través de su dominio tipo lectina, a diversos oligosacáridos, los cuales están usualmente conjugados con proteínas transmembranales. 1 Definition. P-Selektin ist ein Protein, das als Zelladhäsionsmolekül (CAM) auf den Oberflächen von aktivierten Endothelzellen und Thrombozyten fungiert. In inaktiven Endothelzellen wird es in Zellgranula gespeichert, die Weibel-Palade-Körperchen genannt werden, in inaktiven Thrombozyten in den α-Granula .
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Materials and Methods . E- and P-selectin: differences, similarities and implications for the design of P-selectin antagonists. Binder FP (1), Ernst B. Selectins form a family of Ca2+ -dependent carbohydrate binding proteins that mediate the initial step of leukocyte recruitment in the inflammatory process. Blocking of selectins is therefore considered a promising E- and P-selectin: differences, similarities and implications for the design of P-selectin antagonists.

P-Selektin ist ein Protein, das als Zelladhäsionsmolekül (CAM) auf den Oberflächen von aktivierten Endothelzellen und Thrombozyten fungiert. In inaktiven Endothelzellen wird es in Zellgranula gespeichert, die Weibel-Palade-Körperchen genannt werden, in inaktiven Thrombozyten in den α-Granula . E-selectin is a vascular adhesion molecule expressed mainly on endothelium, and its primary role is to facilitate leukocyte cell trafficking by recognizing ligand surface proteins.
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Human Recombinant E-Selectin from CHO cells VWR

mouse E-, and P-selectin-ligand biosynthesis, and the potential that the knockdown 15 Mar 1998 Basically, ligands for L-selectin are found on endothelial cells while ligands for E- and P-selectins are found on leukocytes. Every selectin has While the current study examines binding to P-selectin versus a control substrate with no target-ligand, it is possible to immobilize another ligand like E-selectin in or P-selectin expressed by endothelial cells binds to carbohy- drates borne by show here that the binding of E- or P-selectins by specific antibodies induces.

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Simple Plex Cartridge Kit for 72 samples, containing E-Selectin for use with Human Plasma/Serum. Includes wash buffer and sample diluent. For use with the Ella automated immunoassay system.